🚀 Say Hello to our Brand New Website 🚀

Human chorionic gonadotropin (hCG) is a glycoprotein hormone, made up of an alpha and beta subunit, that is produced by the placenta and normally is only measurable during pregnancy. Some abnormal tissues and cancers, however, may also produce hCG, making the hCG test useful as a tumour marker in certain people, for example if a suspicious lesion is diagnosed on a scan. The markers is used to help diagnose or monitor gestational trophoblastic disease or germ cell testicular tumours.

HCG can be secreted by abnormal germ cell, placental or embryonal tissues especially seminomatous and non-seminomatous testicular tumours (NSGCT), ovarian germ cell tumours, gestational trophoblastic disease (GTD – hydatiform mole and choriocarcinoma) and benign or malignant non-testicular teratomas.

HCG is most appropriately used in monitoring disease progression or effectiveness of treatment once diagnosis of the tumour has been made and serum concentrations have been shown to be high prior to treatment.

As with most tumour markers there is a high incidence of false positive and false negative results.