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C-Reactive Protein (CRP) is an inflammation marker used to assess whether there is inflammation in the body – it does not identify where the inflammation is located. High Sensitivity CRP (CRP-hs) is a test used to detect low-level inflammation thought to damage blood vessels which can lead to a heart attack or stroke. When you suffer a serious injury or infection you experience significant inflammation around the site of injury – such as the swelling around a twisted ankle. Any injury like this will cause your CRP-hs to rise.