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Cholesterol in your body is generally broken down into 2 main components; HDL and LDL. However there are other types of cholesterol such as VLDL (very low-density lipoproteins) and other lipoproteins which are thought to be even more harmful than LDL cholesterol. Non-HDL cholesterol is calculated by subtracting your HDL cholesterol value from your total cholesterol. It therefore includes all the potentially harmful cholesterol in your blood including LDL. As such, it is considered to be a better marker for cardiovascular risk than total cholesterol and LDL cholesterol.