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Thyroglobulin antibodies are antibodies produced for the protein Thyroglobulin, which is specific to the thyroid gland. Under normal circumstances it does not enter the bloodstream, but if your thyroid is inflamed or under attack from the body’s own immune system, then thyroglobulin can be secreted and antibodies detected. Most cases of thyroid disease are caused by an autoimmune condition where the thyroid gland is attacked by the body’s own immune system. This can cause the thyroid gland to produce more thyroid hormone (as in the case of Graves’ disease) or to produce less as the cells in the thyroid gland are gradually destroyed (as in the case of Hashimoto’s thyroiditis).